Senolytics

Findings: Of the 10 flavonoids tested, fisetin was the most potent senolytic. Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.”

Crystals

A recent article in the L.A. Times says that the “new thing rich people are into: absolutely enormous crystals…”

“Over the years, what I have found with the very wealthy is that they are into alternative methods of everything,” said Rayni Williams, a top luxury real estate agent and co-founder of brokerage firm the Beverly Hills Estates. She’s a believer, too, always carrying black tourmaline with her to ward off “a negative force coming toward you” and outfitting her new Sunset Strip office with a pair of 4 1/2-foot-tall amethysts, a rose quartz boulder weighing several hundred pounds and, in one corner, a slab of citrine — the yellow-orange stone “brings abundance,” Williams said, and is for “accruing good real estate and protecting your assets.”

L.A. Times, Aug. 1, 2021